RESEARCH

Research

Informing Clinical Practice

Mr Addison has been involved in high quality basic-science and clinical research throughout his training and career. 

As a medical student at Cambridge University, he obtained a First Class degree, one third of which was awarded for his original laboratory research project in Pharmacology. As a trainee in eye surgery, Mr Addison completed clinical research projects in ocular oncology at St Bartholomew’s Hospital, London and in cataract surgery at The Cambridge University Teaching Hospitals. During two years of full-time clinical and laboratory research on the molecular genetics of inherited human cataract at the UCL Institute of Ophthalmology, Mr Addison discovered and published papers on novel molecular genetic causes of inherited cataracts. He was awarded his Doctorate of Medicine degree after completing his thesis, which is accessible via The British Library.

As a Consultant, Mr Addison has continued to be actively involved in research, with a special interest in novel therapies to treat Medical Retinal and Uveitis disorders. He aims to ensure that his patients have access to the very latest cutting-edge therapies for their conditions, which he can deliver to them as soon as there is clinical evidence to support their use, often having been closely involved in generating that evidence or trialling those treatments in local, national and international studies. Since 2012, Mr Addison has been a co-investigator on 12 different international clinical trials including those investigating novel therapies for wet and dry age-related macular degeneration, retinal vein occlusion, uveitis and novel gene therapy for inherited eye disease. He is currently the principal investigator for a national study on the genetics of steroid induced intra-ocular pressure rise.  Previously, he was principal investigator for an international randomised controlled trial on central retinal vein occlusion.

Please find below a list of Mr Addison's publications and presentations:
Publications in Peer Reviewed Journals
  1. Inparaj S, Testi I, Addison P. Birdshot retinochoroiditis. Eye News June/July 2022; vol 29:1 
  2. Burke T, Addison PK, Pavesio CE. Multifocal evanescent white dot syndrome-like phenotypes associated with inflammatory and myopic choroidal neovascularization. Ocul Immunol Inflamm. June 2021
  3. Testi I, Addison PK, Nolan W, Pavesio CE. Severe hypotony-induced intraocular inflammation after removal of ripcord suture from a glaucoma drainage device in uveitis patient. Ocul Immunol Inflamm. April 2021.
  4. Patel PJ, Jayaram H, Eleftheriadou M, Vazquez-Alfageme C, Islam N, Rubin GS, Pal B, Addison PK, Hamilton R, Degli Esposti S. Individualizing Therapy for Neovascular Age-Related Macular Degeneration with Aflibercept (VITAL): A Two-Year Prospective, Interventional Single-Centre Trial. Ophthalmology and Therapy September 2020; 9(3):563-576.
  5. Eleftheriadou M, Nicholson L, d’Alonzo G, Addison PKF. Real-life evidence for using a treat-and-extend injection regime for patients with central retinal vein occlusion. Ophthalmology and Therapy April 2019; 8:289-296.
  6. Agrawal R, Grant R, Gupta B, Gunasekeran DV, Gonzalez-Lopez JJ, Addison PKF, Westcott M, Pavesio CE. What does IGRA testing add to the diagnosis of ocular tuberculosis? A Bayesian latent class analysis. BMC Ophthalmol. 2017 Dec 8; 17(1):245.
  7. Agrawal R, Gunasekeran DV, Gonzalez-Lopez JJ, Cardoso J, Gupta B, Addison PK, Westcott M, Pavesio CE. Peripheral retinal vasculitis: Analysis of 110 Consecutive Cases and a Contemporary Reappraisal of Tubercular Etiology.  Retina 2017 Jan; 37(1):112-117.
  8.  Nobre Cardoso J, Keane PA, Sim DA, Bradley P, Agrawal R, Addison PK, Egan C, Tufail A. Systematic Evaluation of Optical Coherence Tomography Angiography in Retinal Vein Occlusion. Am J Ophthalmol. 2016 Mar;163:93-107. 
  9. Agrawal R, Gonzalez-Lopez JJ, Nobre-Cardoso J, Gupta B, Grant R, Addison PK, Westcott M, Pavesio CE. Predictive factors for treatment failure in patients with presumed ocular tuberculosis in an area of low endemic prevalence. Br J Ophthalmol. 2016 Mar;100(3):348-55. 
  10. Agrawal R, Gupta B, Gonzalez-Lopez J, Cardoso J, Triantafullopoulou I, Grant R, Addison PK, Westcott M, Pavesio CE. Spectrum of choroidal involvement in presumed ocular Tuberculosis: Report from a population with low endemic setting for Tuberculosis. Ocul Immunol Inflamm. 2016 Jan;1-7. 
  11. Agrawal R, Bhan K, Balaggan K, Lee R, Pavesio CE, Addison PK. Unilateral Acute Maculopathy Associated with Adult Onset Hand Foot and Mouth Disease: Case report and review of literature. Journal of Ophthalmic Inflamm Infect. 2015 Feb 5:2.
  12. Agrawal R, Gupta B, Gonzalez-Lopez JJ, Rahman F, Phatak S, Triantafyllopoulou I, Addison PK, Westcott M, Pavesio CE. The role of anti tubercular therapy (ATT) in patients with presumed ocular tuberculosis. Ocul Immunol Inflamm. 2015 Feb;23(1):40-6. 
  13. Agrawal R, Addison P, Saihan Z, Pefkianaki M, Pavesio C. Optic neuropathy secondary to Linezolid for Multi Drug Resistant (MDR) mycobacterial spinal Tuberculosis. Ocul Immunol Inflamm. 2015 Feb;23(1):90-2. 
  14. Couture S, Agrawal R, Woods K, Lockwood D, Pavesio CE, Addison PK. A case of panuveitis with hypopyon due to presumed ocular leishmaniasis in a HIV patient. J Ophthalmic Inflamm Infect. 2014 Dec;4(1):21. 
  15. Agrawal R, Fernandez-Sanz G, Bala S, Addison PK. Desegmentation of Ozurdex implant in vitreous cavity: report of two cases. Br J Ophthalmol. 2014 Jul;98(7):961-3. 
  16. Addison PK, Rajendram R, Bradshaw H, Hykin PG. Using data from the Cataract National Dataset electronic multicentre audit to calculate risk of posterior capsule rupture and vitreous loss for patients on current surgical lists. Eye 2011; 25:396-7.  
  17. Addison PK, Papadopoulos M, Nischal KK, Hykin PG. Serous retinal detachment induced by topical bimatoprost in a patient with Sturge-Weber syndrome. Eye 2011; 25:124-5. 
  18. Arora A, Minogue PJ, Liu X, Addison PK, Russell-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT. A novel connexin 50 mutation associated with congenital nuclear pulverulent cataract. J Med Genet 2008; 45:155-60.
  19. Addison PK, Berry V, Holden KR, Espinal D, Rivera B, Su H, Srivastava AK, Bhattacharya SS. A novel mutation in the connexin 46 gene (GJA3) causes autosomal dominant zonular pulverulent cataract in a Hispanic family. Molecular Vision 2006; 12:791-5. 
  20. Gombos DS, Cauchi PA, Hungerford JL, Addison P, Coen PG, Kingston JE. Vitreous relapse following primary chemotherapy for retinoblastoma: Is adjuvant diode laser a risk factor? Br J Ophthalmol 2006; 90:1168-1172. 
  21. Addison PK. Clinical, molecular genetic and functional studies on inherited human cataracts. MD thesis 2006 (University of London). 
  22. Addison PK, Berry V, Ionides ACW, Francis PJ, Bhattacharya SS, Moore AT. Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. Br J Ophthalmol 2005; 89:138-141. 
  23. Berry V, Yang Z, Addison PK, Francis PJ, Ionides A, Karan G, Jiang L, Lin W, Hu J, Yang R, Moore A, Zhang K and Bhattacharya SS. Recurrent 17bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). J Med Genet 2004; 41(8): e109. 
  24. Addison PK, Snead DJ, Snead MP. Radiation retinopathy secondary to radiotherapy for lower lid BCC. Eye 2004; 18(12):1273-4. 
Presentations at International Meetings since 2019 
  1. Addison PKF. Challenging retinal vein occlusion cases. Oral presentation at Retinal Pioneers Summit, London, July 2022.
  2. Addison PKF. Ocular steroid injections. Oral presentation at Moorfields Macular Course, London, June 2022.
  3. Addison PKF. When is steroid first line therapy in RVO? Oral presentation at Beyond Retina National Meeting, London, November 2021.
  4. Addison PKF. Dexamethasone implant in uveitis. Oral presentation at Royal College of Ophthalmologists Annual Congress, May 2021
  5. Addison PKF. Real-life evidence for Eylea in CRVO. Retinal pioneers summit, London, January 2020.
  6. Addison PKF. A systematic programme of core clinical outcomes. Oral presentation at World Association of Eye Hospitals 13th Annual Meeting, London, June 2019.
  7. Tucker W, Sethi CJ, Kumaran N, Nicholson L, Addison PKF, Stanford M. The Pan-London Ozurdex in Posterior Uveitis survey. Poster presentation at the Royal College of Ophthalmologists Annual Congress, Glasgow, May 2019.
  8. Esposti SD, Gemenetzi M, Eleftheriadou M, Jayaram H, Pal B, Islam N, Addison P, Hamilton R, Patel P. Individualising therapy for neovascular age-related macular degeneration with aflibercept – the VITAL study. Poster presentation at Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Vancouver, April 2019.
  9. M Gkika, Hamilton R, Addison P, Pal B. Treat and Extend aflibercept in the treatment of macular edema due to CRVO: 18 months results of real-life data. Poster presentation at Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Vancouver, April 2019.
  10. Burke T, Addison PKF, Pavesio C. Multifocal evanescent white dot syndrome following inflammatory and myopic choroidal neovascularization. Poster presentation at ARVO, Vancouver, April 2019.
  11. Braithwaite T, Delisser, J Virgo, J, Hindle E, Tucker W, Petrushkin H, Rees A, Thomas D, Westcott Mark, Addison P, Pavesio C, Lee RW, Denniston AK, Okhravi N. Oral immunosuppression practice for inflammatory eye disease: a one-year analysis of prescriptions at Moorfields Eye Hospital. Poster presentation at ARVO, Vancouver, April 2019
  12. Eleftheriadou M, Nicholson L, D’Alonzo G, Addison PKF. Real–life evidence for using a treat-and-extend injection regime for patients with central retinal vein occlusion. Poster presentation at ARVO, Vancouver, April 2019 
Presentations at Regional Ophthalmology Meetings Since 2019 
 Mr Addison teaches doctors about Retinal Vein Occlusion (RVO) through regular lectures on the national and international Moorfields Preceptorship programmes, through the Medical Retina Service teaching programme and through invited lectures nationally and regionally. He also teaches postgraduate students about RVO and steroid-sparing treatments for inflammatory eye disease through annual lectures including case-based learning on the Ophthalmology MSc course at UCL Institute of Ophthalmology. He teaches a range of allied health professionals on RVO through regular lecturing for the Moorfields Optometry department and invited lecturing at meetings such as the nurses and allied health professionals London symposium on RVO in March 2017.  

 In addition to these regular teaching commitments, the following is a list of recent presentations. 
  1. Addison PKF. A systematic programme of core clinical outcomes. Oral presentation at Moorfields Clinical Governance half day Meeting, London, October 2021.
  2. Addison PKF. Fluoroscein conference, Moorfields Eye Hospital, London, June 2021
  3. Addison PKF. Uveitis and retinal case presentations. North East Thames Regional teaching, Royal Free Hospital, London, July 2021, June 2020 and May 2016.
  4. Addison PKF. Acute retinal necrosis, Uveitis teaching, Moorfields Eye Hospital, London June 2020
  5. Addison PKF. Indocyanine green angiography. Moorfields Macular Course, London, November 2019.
  6. Addison PKF. Chairmanship of the Quality improvement through audit and innovation section of the annual Moorfields Trustwide Clinical Governance half-day at The Barbican, London, November 2019, November 2018 and November 2017.
  7. Bohn M, Addison PKF. Fluoroscein conference, Moorfields Eye Hospital, London, June 2019
  8. Addison PKF, Rogers D. Showcasing the Moorfields to St Thomas’ Uveitis pathway. Uveitis regional teaching session, Moorfields Eye Hospital, London, April 2019.
  9. Addison PKF, Stanford M. Chairmanship of the London Inflammatory Ocular Network (LION) Annual meeting, April 2019.
  10. Addison PKF. Chairmanship of the London and South East Retina update meeting. The Strand, London, March 2019.
  11. Addison PKF. Treatment of retinal vein occlusion. Webcast. February 2019.
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